Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Abstract

Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.

Keywords

• Apoptosis
• Autophagic dysfunction
• Insulin resistance
• Islet beta cell dysfunction
• Type 2 diabetes mellitus