Quantitative Iodine-123 single-photon emission computed tomography/computed tomography for Iodine-131 therapy of an autonomously functioning thyroid nodule

Abstract

Key points Question: Is it feasible for I-123 SPECT/CT to be used for planning of I-131 therapy in an autonomously functioning thyroid nodule (AFTN)? Pertinent findings: The radioactive iodine uptake of the AFTN and extranodular normal thyroid tissue can be accurately estimated using the I-123 quantitative SPECT/CT. Implications for patient care: Patient-tailored I-131 therapy can be possible using the pre-therapeutic I-123 SPECT/CT-based planning in patients with AFTN.

Keywords

• Radioactive iodine
• Autonomously functioning thyroid nodule
• Toxic nodular goiter
• SPECT/CT
• Cadmium-zinc-telluride
• Quantitation