A distinct assembly pathway of the human 39S late pre-mitoribosome

Jingdong Cheng; Otto Berninghausen; Roland Beckmann

doi:10.1038/s41467-021-24818-x

Nature Communications (Jul 2021)

A distinct assembly pathway of the human 39S late pre-mitoribosome

Jingdong Cheng,
Otto Berninghausen,
Roland Beckmann

Affiliations

Jingdong Cheng: Gene Center and Department for Biochemistry, LMU Munich
Otto Berninghausen: Gene Center and Department for Biochemistry, LMU Munich
Roland Beckmann: Gene Center and Department for Biochemistry, LMU Munich

DOI: https://doi.org/10.1038/s41467-021-24818-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Assembly of the mitoribosome requires assistance from numerous specialized factors. Here, structures of the human 39S late assembly intermediates identify several assembly factors which keep the 16S rRNA in immature conformations, and reveal deacylated tRNA in the ribosomal E-site, suggesting a role in 39S assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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