Taiwanese Journal of Obstetrics & Gynecology (Jun 2018)

Rare case of undifferentiated uterine sarcoma with neuroectodermal differentiation and osteoclast-like giant cells

  • Chiu-Hsuan Cheng,
  • Borcherng Su,
  • Dah-Ching Ding

DOI
https://doi.org/10.1016/j.tjog.2018.04.020
Journal volume & issue
Vol. 57, no. 3
pp. 442 – 446

Abstract

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Objective: We describe the first case of a rare undifferentiated uterine sarcoma exhibiting both neuroectodermal differentiation and osteoclast-like giant cells, and elaborate its morphology. Case report: A 54-year-old woman presented with suprapubic pain, frequent urination, and perimenopausal abnormal vaginal bleeding. Computed tomography revealed a large heterogeneous uterine mass and multiple lung nodules. She received a staging surgery. The tumor pathology examination revealed an undifferentiated uterine sarcoma (UUS) with neuroectodermal differentiation and osteoclast-like giant cells (OGCs). The patient was managed with palliative hospice care; however, she died within 1.5 months of diagnosis. Conclusion: UUSs are rare high-grade tumors observed in elderly women. These women typically present with postmenopausal bleeding and extrauterine diseases and have a poor prognosis. Neuroectodermal differentiation in UUSs has a müllerian origin. The presence of OGCs may suggest a poor prognosis; however, further studies are necessary to determine the exact nature of such neoplasms.

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