Антибиотики и Химиотерапия (May 2020)

In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen

  • S. YA. Loginova,
  • S. V. Borisevich,
  • V. A. Maksimov,
  • V. P. Bondarev,
  • V. E. Nebolsin

Journal volume & issue
Vol. 54, no. 7-8
pp. 16 – 18

Abstract

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The experimental investigation of the Ingavirin® antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin® amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin® was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture.

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