The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2

Abstract

Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.

Keywords

• diabetes mellitus type 2
• diabetic nephropathy
• chronic kidney disease
• coagulopathy
• iterleikin-6
• homocystein
• inflammation