Nature Communications (Feb 2021)
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
- James M. Roe,
- Didac Vidal-Piñeiro,
- Øystein Sørensen,
- Andreas M. Brandmaier,
- Sandra Düzel,
- Hector A. Gonzalez,
- Rogier A. Kievit,
- Ethan Knights,
- Simone Kühn,
- Ulman Lindenberger,
- Athanasia M. Mowinckel,
- Lars Nyberg,
- Denise C. Park,
- Sara Pudas,
- Melissa M. Rundle,
- Kristine B. Walhovd,
- Anders M. Fjell,
- René Westerhausen,
- The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Affiliations
- James M. Roe
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- Didac Vidal-Piñeiro
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- Øystein Sørensen
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- Andreas M. Brandmaier
- Center for Lifespan Psychology, Max Planck Institute for Human Development
- Sandra Düzel
- Center for Lifespan Psychology, Max Planck Institute for Human Development
- Hector A. Gonzalez
- Center for Vital Longevity, University of Texas
- Rogier A. Kievit
- MRC Cognition and Brain Sciences Unit, University of Cambridge
- Ethan Knights
- MRC Cognition and Brain Sciences Unit, University of Cambridge
- Simone Kühn
- Center for Lifespan Psychology, Max Planck Institute for Human Development
- Ulman Lindenberger
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf
- Athanasia M. Mowinckel
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- Lars Nyberg
- Umeå Center for Functional Brain Imaging and Department of Integrative Medical Biology, Umeå University
- Denise C. Park
- Center for Vital Longevity, University of Texas
- Sara Pudas
- Umeå Center for Functional Brain Imaging and Department of Integrative Medical Biology, Umeå University
- Melissa M. Rundle
- Center for Vital Longevity, University of Texas
- Kristine B. Walhovd
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- Anders M. Fjell
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- René Westerhausen
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo
- The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
- DOI
- https://doi.org/10.1038/s41467-021-21057-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Cortical thickness is asymmetric, and cortical thinning occurs with age and in disease. Here the authors investigate if both cortices thin at the same rate or if the thicker hemisphere declines faster in aging and in Alzheimer’s disease.
