PLoS ONE (Jan 2021)

Changing epidemiology of catheter-related bloodstream infections in neutropenic oncohematological patients.

  • Dajana Lendak,
  • Pedro Puerta-Alcalde,
  • Estela Moreno-García,
  • Mariana Chumbita,
  • Nicole García-Pouton,
  • Celia Cardozo,
  • Laura Morata,
  • Maria Suárez-Lledó,
  • Marta Hernández-Meneses,
  • Lucio Ghiglione,
  • Francesc Marco,
  • Jose Antonio Martinez,
  • Josep Mensa,
  • Ivana Urošević,
  • Alex Soriano,
  • Carolina Garcia-Vidal

DOI
https://doi.org/10.1371/journal.pone.0251010
Journal volume & issue
Vol. 16, no. 4
p. e0251010

Abstract

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BackgroundWe aimed to describe the epidemiology of catheter-related bloodstream infections (CRBSIs) in onco-hematological neutropenic patients during a 25-year study period, to evaluate the risk factors for Gram-negative bacilli (GNB) CRBSI, as well as rates of inappropriate empirical antibiotic treatments (IEAT) and mortality.Materials/methodsAll consecutive episodes of CRBSIs were prospectively collected (1994-2018). Changing epidemiology was evaluated comparing five-year time spans. A multivariate regression model was built to evaluate risk factors for GNB CRBSIs.Results482 monomicrobial CRBSIs were documented. The proportion of CRBSIs among all BSIs decreased over time from 41.2% to 15.8% (pConclusionA significant shift towards GNB-CRBSIs was observed. Secondarily, and coinciding with an increasing number of GNB-MDR infections, mortality increased over time.