Structure of the human marker of self 5-transmembrane receptor CD47

Gustavo Fenalti; Nicolas Villanueva; Mark Griffith; Barbra Pagarigan; Sirish Kaushik Lakkaraju; Richard Y.-C. Huang; Nadia Ladygina; Alok Sharma; David Mikolon; Mahan Abbasian; Jeffrey Johnson; Haralambos Hadjivassiliou; Dan Zhu; Philip P. Chamberlain; Ho Cho; Kandasamy Hariharan

doi:10.1038/s41467-021-25475-w

Nature Communications (Sep 2021)

Structure of the human marker of self 5-transmembrane receptor CD47

Gustavo Fenalti,
Nicolas Villanueva,
Mark Griffith,
Barbra Pagarigan,
Sirish Kaushik Lakkaraju,
Richard Y.-C. Huang,
Nadia Ladygina,
Alok Sharma,
David Mikolon,
Mahan Abbasian,
Jeffrey Johnson,
Haralambos Hadjivassiliou,
Dan Zhu,
Philip P. Chamberlain,
Ho Cho,
Kandasamy Hariharan

Affiliations

Gustavo Fenalti: Molecular Structure and Design, Bristol Myers Squibb
Nicolas Villanueva: Molecular Structure and Design, Bristol Myers Squibb
Mark Griffith: Protein Homeostasis, Bristol Myers Squibb
Barbra Pagarigan: Molecular Structure and Design, Bristol Myers Squibb
Sirish Kaushik Lakkaraju: Molecular Structure and Design, Bristol Myers Squibb
Richard Y.-C. Huang: Pharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers Squibb
Nadia Ladygina: Pharmacology, Bristol Myers Squibb
Alok Sharma: Molecular Structure and Design, Bristol Myers Squibb
David Mikolon: Discovery Biotherapeutics, Bristol Myers Squibb
Mahan Abbasian: Discovery Biotherapeutics, Bristol Myers Squibb
Jeffrey Johnson: Discovery Biotherapeutics, Bristol Myers Squibb
Haralambos Hadjivassiliou: Discovery Biotherapeutics, Bristol Myers Squibb
Dan Zhu: Discovery Biotherapeutics, Bristol Myers Squibb
Philip P. Chamberlain: Protein Homeostasis, Bristol Myers Squibb
Ho Cho: Discovery Biotherapeutics, Bristol Myers Squibb
Kandasamy Hariharan: Discovery Biotherapeutics, Bristol Myers Squibb

DOI: https://doi.org/10.1038/s41467-021-25475-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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