Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

G. Torromino; L. Autore; V. Khalil; V. Mastrorilli; M. Griguoli; A. Pignataro; E. Centofante; G. M. Biasini; V. De Turris; M. Ammassari-Teule; A. Rinaldi; A. Mele

doi:10.1038/s41467-019-13703-3

Nature Communications (Dec 2019)

Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

G. Torromino,
L. Autore,
V. Khalil,
V. Mastrorilli,
M. Griguoli,
A. Pignataro,
E. Centofante,
G. M. Biasini,
V. De Turris,
M. Ammassari-Teule,
A. Rinaldi,
A. Mele

Affiliations

G. Torromino: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
L. Autore: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
V. Khalil: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
V. Mastrorilli: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
M. Griguoli: European Brain Research Institute (EBRI)
A. Pignataro: CNR - National Research Council, Institute of Translational Pharmacology
E. Centofante: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
G. M. Biasini: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
V. De Turris: Center for Life Nanotechnology - Nanotechnology for Neuroscience, Istituto Italiano di Tecnologia (IIT)
M. Ammassari-Teule: Laboratory of Psychobiology, Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
A. Rinaldi: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome
A. Mele: Department of Biology and Biotechnology ‘C. Darwin’, Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome

DOI: https://doi.org/10.1038/s41467-019-13703-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Spatial information is passed from the hippocampus via the subiculum to the ventral striatum. Here, the authors show that inhibiting this projection after spatial learning disrupts learning induced plasticity and spatial memory consolidation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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