Frontiers in Cardiovascular Medicine (Feb 2022)

The Burden of Ventricular Premature Complex Is Associated With Cardiovascular Mortality

  • Po-Tseng Lee,
  • Po-Tseng Lee,
  • Ting-Chun Huang,
  • Ting-Chun Huang,
  • Mu-Hsiang Huang,
  • Ling-Wei Hsu,
  • Pei-Fang Su,
  • Yen-Wen Liu,
  • Yen-Wen Liu,
  • Meng-Hsuan Hung,
  • Ping-Yen Liu,
  • Ping-Yen Liu

DOI
https://doi.org/10.3389/fcvm.2021.797976
Journal volume & issue
Vol. 8

Abstract

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BackgroundVentricular premature complex (VPC) is one of the most common ventricular arrhythmias. The presence of VPC is associated with an increased risk of heart failure (HF).MethodWe designed a single-center, retrospective, and large population-based cohort to clarify the role of VPC burden in long-term prognosis in Taiwan. We analyzed the database from the National Cheng Kung University Hospital-Electronic Medical Record (NCKUH-EMR) and NCKUH-Holter (NCKUH-Holter). A total of 19,527 patients who underwent 24-h Holter ECG monitoring due to palpitation, syncope, and clinical suspicion of arrhythmias were enrolled in this study.ResultsThe clinical outcome of interests involved 5.65% noncardiovascular death and 1.53% cardiovascular-specific deaths between 2011 and 2018. Multivariate Cox regression analysis, Fine and Gray's competing risk model, and propensity score matching demonstrated that both moderate (1,000–10,000/day) and high (>10,000/day) VPC burdens contributed to cardiovascular death in comparison with a low VPC burden (<1,000/day).ConclusionA higher VPC burden via Holter ECG is an independent risk factor of cardiovascular mortality.

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