Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

Chad M. Glen; Todd C. McDevitt; Melissa L. Kemp

doi:10.1038/s41467-018-06693-1

Nature Communications (Oct 2018)

Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

Chad M. Glen,
Todd C. McDevitt,
Melissa L. Kemp

Affiliations

Chad M. Glen: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Todd C. McDevitt: Gladstone Institute of Cardiovascular Disease
Melissa L. Kemp: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

DOI: https://doi.org/10.1038/s41467-018-06693-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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How heterogeneities arise in stem cell populations remains unclear. Here, Glen et al. find that in ESC colonies cell cycle asynchronies modulate gap junctions, causing variation in intracellular signalling molecule diffusion between cells, and ultimately in spatial heterogeneity in differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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