МЕТАБОЛИЧЕСКИЕ ЭФФЕКТЫ ОМЕГА–3 ЭФИРОВ ФИТОСТЕРОЛОВ У ПАЦИЕНТОВ С ГИПЕРЛИПИДЕМИЕЙ СМЕШАННОГО ТИПА

Abstract

The aim of the current study was to evaluate the therapeutic effects of omega–3 plant sterol esters (n–3–PSE) on lipid profile and other coronary heart disease risk factors in subjects with mixed hyperlipidemia. N–3–PSE treatment did not result in a significant change in LDL–C levels. Triglyceride levels were reduced significantly in the n–3–PSE group in comparison with the placebo group (p = 0.025). Diastolic blood pressure and level of high-sensitivity C–reactive protein (hsCRP) were reduced significantly, too. So, in patients with mixed hyperlipidemia, n–3–PSE treatment may offer a safe and effective therapy for triglyceride level reduction while avoiding the typical increase in LDL–C levels associated with n–3 fatty acid treatment. The observed reduction in blood pressure and inflammation markers warrants further evaluation. The positive effect of n–3–PSE treatment was preserved at the end of the follow up phase.

Keywords

• hypertriglyceridemia
• dyslipidemia
• plant sterol esters
• n–3 fatty acids
• high–sensitivity c–reactive protein (hscrp)