AND-1 fork protection function prevents fork resection and is essential for proliferation

Takuya Abe; Ryotaro Kawasumi; Michele Giannattasio; Sabrina Dusi; Yui Yoshimoto; Keiji Miyata; Koyuki Umemura; Kouji Hirota; Dana Branzei

doi:10.1038/s41467-018-05586-7

Nature Communications (Aug 2018)

AND-1 fork protection function prevents fork resection and is essential for proliferation

Takuya Abe,
Ryotaro Kawasumi,
Michele Giannattasio,
Sabrina Dusi,
Yui Yoshimoto,
Keiji Miyata,
Koyuki Umemura,
Kouji Hirota,
Dana Branzei

Affiliations

Takuya Abe: IFOM, the FIRC Institute of Molecular Oncology
Ryotaro Kawasumi: IFOM, the FIRC Institute of Molecular Oncology
Michele Giannattasio: IFOM, the FIRC Institute of Molecular Oncology
Sabrina Dusi: IFOM, the FIRC Institute of Molecular Oncology
Yui Yoshimoto: Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
Keiji Miyata: Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
Koyuki Umemura: Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
Kouji Hirota: Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
Dana Branzei: IFOM, the FIRC Institute of Molecular Oncology

DOI: https://doi.org/10.1038/s41467-018-05586-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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AND-1, the vertebrate orthologue of Ctf4, is a critical player during DNA replication and for maintenance of genome integrity. Here the authors use a conditional AND-1 depletion system in avian DT40 cells to reveal the consequences of the lack of AND-1 on cell proliferation and DNA replication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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