Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

Tong Liu; Deli Song; Jianzeng Dong; Pinghui Zhu; Jie Liu; Jie Liu; Wei Liu; Xiaohai Ma; Lei Zhao; Shukuan Ling

doi:10.3389/fphys.2017.00238

Frontiers in Physiology (Apr 2017)

Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

Tong Liu,
Deli Song,
Jianzeng Dong,
Pinghui Zhu,
Jie Liu,
Jie Liu,
Wei Liu,
Xiaohai Ma,
Lei Zhao,
Shukuan Ling

Affiliations

Tong Liu: Department of Cardiology, Capital Medical University, Beijing AnZhen HospitalBeijing, China
Deli Song: Department of Cardiology, Capital Medical University, Beijing AnZhen HospitalBeijing, China
Jianzeng Dong: Department of Cardiology, Capital Medical University, Beijing AnZhen HospitalBeijing, China
Pinghui Zhu: Department of Cardiology, Beijing Changping HospitalBeijing, China
Jie Liu: Department of Vascular Surgery, Chinese PLA General HospitalBeijing, China
Jie Liu: Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical SchoolBoston, MA, USA
Wei Liu: Department of Cardiology, Capital Medical University, Beijing AnZhen HospitalBeijing, China
Xiaohai Ma: Department of Radiology, Beijing Anzhen Hospital, Capital Medical UniversityBeijing, China
Lei Zhao: Department of Radiology, Beijing Anzhen Hospital, Capital Medical UniversityBeijing, China
Shukuan Ling: State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterBeijing, China

DOI: https://doi.org/10.3389/fphys.2017.00238
Journal volume & issue: Vol. 8

Abstract

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Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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