Inertial-Assisted Immunomagnetic Bioplatform towards Efficient Enrichment of Circulating Tumor Cells
Yixing Gou,
Jiawen Liu,
Changku Sun,
Peng Wang,
Zheng You,
Dahai Ren
Affiliations
Yixing Gou
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China
Jiawen Liu
State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
Changku Sun
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China
Peng Wang
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China
Zheng You
State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
Dahai Ren
State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
Serving as an effective biomarker in liquid biopsy, circulating tumor cells (CTCs) can provide an accessible source for cancer biology study. For the in-depth evaluation of CTCs in cancer analysis, their efficient enrichment is essential, owing to their low abundance in peripheral blood. In this paper, self-assembled immunomagnetic beads were developed to isolate CTCs from the ordered bundles of cells under the assistance of the spiral inertial effect. Parametric numerical simulations were performed to explore the velocity distribution in the cross section. Based on this chip, rare CTCs could be recovered under the throughput of 500 μL/min, making this device a valuable supplement in cancer analysis, diagnostics, and therapeutics.
