Comparison between oscillometric- and Doppler-ABI in elderly individuals

Abstract

Ikuno Takahashi,1,3 Kyoji Furukawa,2 Waka Ohishi,1 Tetsuya Takahashi,3 Masayasu Matsumoto,3 Saeko Fujiwara11Department of Clinical Studies, 2Department of Statistics, Radiation Effects Research Foundation (RERF), Hiroshima, Japan; 3Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, JapanAbstract: Peripheral arterial disease (PAD) generally remains under-recognized, mainly due to the specialized technical skills required to detect the low values of the ankle-brachial index (ABI). As a simpler and faster alternative to the standard method using continuous-wave Doppler ultrasound, we evaluated automated oscillometric ABI measurement by VP-2000 with an elderly cohort of 113 subjects (age range, 61 to 88 years). The standard deviation in ABIs measured by the Doppler method was statistically greater than that measured by the oscillometric method for each of the two legs (P < 0.001). Correlations in ABIs between the two methods were 0.46 for the left leg and 0.61 for the right leg; this result appears to have been caused by interobserver variation in the Doppler ABI measurements. While the trend showing greater differences between average oscillometric- and Doppler-ABIs was significant at the lower ABI ranges, there was little indication of differences in measurements having an average ABI > 1.1. The difference between the methods was suggestively larger in subjects who were smokers than in non-smokers (P = 0.09), but the difference was not affected by other potential atherosclerotic risk factors, including age at examination (P > 0.50). A larger difference at lower ABIs led to better PAD detection by the Doppler method compared to the oscillometric method (sensitivity = 50%, specificity = 100%), although the overall agreement was not small (Cohen's Kappa = 0.65). Our findings indicate that oscillometric devices can provide more accurate estimation of the prevalence of PAD in elderly individuals than the conventional Doppler method.Keywords: ankle-brachial index, oscillometry, Doppler, peripheral arterial disease