Vascular endothelial growth factor (VEGF)-C and its receptors, soluble VEGFR-2 and VEGFR-3, in polycystic ovary syndrome

Abstract

Angiogenesis is involved in polycystic ovary syndrome (PCOS) progression. Vascular endothelial growth factor-C (VEGF-C) and its receptors are key angiogenic markers. The main objective of this study was to investigate the serum levels of VEGF-C and its receptors, soluble VEGF receptor 2 (sVEGFR-2) and VEGFR-3, in patients with PCOS and healthy controls and determine the link between serum levels of these VEGF-related proteins and the biochemical and hormonal data of patients with PCOS.

Keywords

• polycystic ovary syndrome
• growth factors
• vascular endothelial growth factor receptors
• inflammation
• anti-müllerian hormone