Investigation of the effect of CA IX enzyme inhibition on the EZH2 gene and histone 3 modifications

Abstract

Colon cancer is the most common gastrointestinal cancer worldwide with high morbidity and mortality rates. The main purpose of our study is to elucidate the interaction mechanism of the H+ ion concentration effect in the CO2/HCO3 − buffer system of tumor-associated carbonic anhydrase IX (CA IX) enzyme inhibition in the HT-29 colon cancer cell line on cell epigenetic modifications.

Keywords

• ca ix
• h3 modifications
• colon cancer
• ezh2
• hif1a