The Association between Cafestol and Cardiovascular Diseases: A Comprehensive Review
Wen-Rui Hao,
Chun-Yao Cheng,
Huan-Yuan Chen,
Jin-Jer Chen,
Tzu-Hurng Cheng,
Ju-Chi Liu
Affiliations
Wen-Rui Hao
Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan
Chun-Yao Cheng
Department of Medical Education, National Taiwan University Hospital, Taipei 100225, Taiwan
Huan-Yuan Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
Jin-Jer Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
Tzu-Hurng Cheng
Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404333, Taiwan
Ju-Chi Liu
Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan
Cafestol, a bioactive compound found in coffee, has attracted considerable attention due to its potential impact on cardiovascular health. This review aims to comprehensively explore the association between cafestol and cardiovascular diseases. We delve into the mechanisms through which cafestol influences lipid metabolism, inflammation, and endothelial function, all of which are pivotal in cardiovascular pathophysiology. Moreover, we meticulously analyze epidemiological studies and clinical trials to elucidate the relationship between cafestol and cardiovascular outcomes. Through a critical examination of existing literature, we aim to provide insights into the potential benefits and risks associated with cafestol concerning cardiovascular health.
