Nature Communications (Nov 2021)
SARS-CoV-2 infection and replication in human gastric organoids
- Giovanni Giuseppe Giobbe,
- Francesco Bonfante,
- Brendan C. Jones,
- Onelia Gagliano,
- Camilla Luni,
- Elisa Zambaiti,
- Silvia Perin,
- Cecilia Laterza,
- Georg Busslinger,
- Hannah Stuart,
- Matteo Pagliari,
- Alessio Bortolami,
- Eva Mazzetto,
- Anna Manfredi,
- Chiara Colantuono,
- Lucio Di Filippo,
- Alessandro Filippo Pellegata,
- Valentina Panzarin,
- Nikhil Thapar,
- Vivian Sze Wing Li,
- Simon Eaton,
- Davide Cacchiarelli,
- Hans Clevers,
- Nicola Elvassore,
- Paolo De Coppi
Affiliations
- Giovanni Giuseppe Giobbe
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Francesco Bonfante
- Lab. of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie
- Brendan C. Jones
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Onelia Gagliano
- Veneto Institute of Molecular Medicine (VIMM)
- Camilla Luni
- Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University
- Elisa Zambaiti
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Silvia Perin
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Cecilia Laterza
- Veneto Institute of Molecular Medicine (VIMM)
- Georg Busslinger
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht
- Hannah Stuart
- Veneto Institute of Molecular Medicine (VIMM)
- Matteo Pagliari
- Lab. of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie
- Alessio Bortolami
- Lab. of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie
- Eva Mazzetto
- Lab. of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie
- Anna Manfredi
- Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics
- Chiara Colantuono
- Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics
- Lucio Di Filippo
- Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics
- Alessandro Filippo Pellegata
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Valentina Panzarin
- Lab. of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie
- Nikhil Thapar
- Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital
- Vivian Sze Wing Li
- Stem Cell and Cancer Biology Lab, the Francis Crick Institute
- Simon Eaton
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Davide Cacchiarelli
- Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics
- Hans Clevers
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht
- Nicola Elvassore
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- Paolo De Coppi
- Stem Cell and Regenerative Medicine Section, GOS Institute of Child Health, University College London
- DOI
- https://doi.org/10.1038/s41467-021-26762-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can efficiently infect gastric epithelium, suggesting that the stomach might have an active role in fecal-oral transmission.
