Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation
Fuxue Zhang,
Bozhang Xia,
Jiabei Sun,
Yufei Wang,
Jinjin Wang,
Fengfei Xu,
Junge Chen,
Mei Lu,
Xin Yao,
Peter Timashev,
Yuanyuan Zhang,
Meiwan Chen,
Jing Che,
Fangzhou Li,
Xing-Jie Liang
Affiliations
Fuxue Zhang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; Sino-Danish Center for Education and Research, Sino-Danish College of University of Chinese Academy of Sciences, Beijing 100049, China
Bozhang Xia
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Jiabei Sun
China National Institutes for Food and Drug Control, Beijing 102629, China
Yufei Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Jinjin Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Fengfei Xu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Junge Chen
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing 100083, China
Mei Lu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China
Xin Yao
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Peter Timashev
Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
Yuanyuan Zhang
Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
Meiwan Chen
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
Jing Che
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Fangzhou Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Xing-Jie Liang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.
