STUDY OF IMMUNE GENETIC RISK FACTORS OF ARTERIAL HYPERTENSION IN NATIVE AND NON-NATIVE POPULATION OF ALTAY REPUBLIC

Abstract

There had been 935 people examined native to Turochaksky district of the Altai Republic (663 — indigenous people (Tubalars) and 272 — non-indigenous population) so as to identify the proportion of population with hypertension, assessment of risk factors and genetic predisposition to the disease according to the blood systems such as ABO, Rh, MN, P and Kell. The proportion of people with hypertension in the Altai Republic was 38.6 % among Tubalars and 40.8 % among non-indigenous population. The high body mass index (BMI) — (Quetelet index) values and. index: waist / hip and. waist circumference are associated, with risk of hypertension, for both ethnic groups, but only Tubalars have such risk factors as smoking and salt abuse. There had been revealed some ethnic differences in the distribution for such systems as blood group Rh factor, and MN. The indigenous ethnic group is marked with a risk of hypertension for the people with Rh(-) blood group, positive associative connection with the disease for those with the phenotype of MN and the resistance for the persons with the blood group Rh(+) and. the phenotype of NN.

Keywords

• rh
• mn
• p и kell
• hypertension
• risk factors
• blood groups
• erythrocytic (abo
• rh-hr
• kell
• mn) antigens system