Soy Isoflavones Ameliorate Fatty Acid Metabolism of Visceral Adipose Tissue by Increasing the AMPK Activity in Male Rats with Diet-Induced Obesity (DIO)
Jinlong Tan,
Chao Huang,
Qihui Luo,
Wentao Liu,
Dongjing Cheng,
Yifan Li,
Yu Xia,
Chao Li,
Li Tang,
Jing Fang,
Kangcheng Pan,
Yangping Ou,
Anchun Cheng,
Zhengli Chen
Affiliations
Jinlong Tan
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Chao Huang
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Qihui Luo
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Wentao Liu
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Dongjing Cheng
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Yifan Li
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Yu Xia
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Chao Li
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Li Tang
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Jing Fang
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Kangcheng Pan
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Yangping Ou
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Anchun Cheng
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Zhengli Chen
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
Soy isoflavones are natural active ingredients of soy plants that are beneficial to many metabolic diseases, especially obesity. Many studies have reported that obesity is closely related to visceral fatty acid metabolism, but the effect has not been well defined. In this study, we show that soy isoflavones improve visceral fatty acid metabolism in diet-induced obese male rats, which was indicated by reduced body weight and visceral fat cell area, as well as suppressed visceral fat synthesis and accelerated fat hydrolysis. We also found that common components of soy isoflavones, daidzein and genistein, were able to inhibit the lipid accumulation process in 3T3-L1 cells. Moreover, we showed that soy isoflavones can promote on AMP-activated protein kinase (AMPK) activity both in vivo and in vitro, which may be implicated in lipid metabolism regulation of soy isoflavones. Our study demonstrates the potential of soy isoflavones as a mechanism for regulating lipid homeostasis in visceral adipose tissue, proven to be beneficial for obesity treatment.
