P53

Abstract

This study used data from population-based cancer registries and total mortality over the past quarter of a century in NIITPM, Novosibirsk. The follow-up period was from 1985 to 2014. Both registers operated in the two regions, the most typical for the city. The results can be extrapolated to the entire population of Novosibirsk. For long-term analysis we used data from two registers concerning gastric cancer, colorectal cancer and liver cancer. Morbidity and mortality from stomach cancer over the past 25 years have declined, however, the proportion of GC 3–4 (end-stage) remains constant with a tendency to increase. In general, the incidence of colorectal cancer in the Novosibirsk region remains at a consistently high level, but the detection rates of colon cancer in women have increased. Men were exposed to colorectal cancer more frequently than women, especially in the older age groups. Meanwhile the share of detection of colorectal cancer clinical stage 3–4 decreased by one third. With regard to liver cancer, decline was observed over 25 years that is 2.1 times lower that coincide with national trends. At the same time, death rates from liver cancer in Novosibirsk are lower than in Russia as a whole. However, the index of malignancy (the ratio of mortality to incidence) of liver cancer was 0.94 in Novosibirsk. In summary, while there are a variety of long -term monitoring of trends in the incidence of cancer, this requires new research, especially the identification of genetic markers for the prevention and possible introduction in oncologic patients.