Eco-Friendly Syntheses of 2-Substituted Benzoxazoles and 2-Substituted Benzothiazoles from 2-Aminophenols, 2-Aminothiophenols and DMF Derivatives in the Presence of Imidazolium Chloride
Qingqiang Tian,
Wen Luo,
Zongjie Gan,
Dan Li,
Zeshu Dai,
Huajun Wang,
Xuetong Wang,
Jianyong Yuan
Affiliations
Qingqiang Tian
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Wen Luo
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Zongjie Gan
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Dan Li
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Zeshu Dai
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Huajun Wang
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Xuetong Wang
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Jianyong Yuan
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
A simple, economical and metal-free approach to the synthesis of 2-substituted benzoxazoles and 2-substituted benzothiazoles from 2-aminophenols, 2-aminothiophenols and DMF derivatives, only using imidazolium chloride (50% mmol) as promoter without any other additive, was reported. Various 2-substituted benzoxazoles and 2-substituted benzothiazoles were thus prepared in moderate to excellent yields.
