Agriculture and agri-food systems of the highly vulnerable Middle East and North Africa (MENA) region needs a radical transformation under a changing climate. Based on a two-year effort, initially we developed a mega hypothesis on how to achieve climate-smart agri-food transformation in the region. In the study, we hypothesized that “Climate-Smart Lifts” implemented in the enabling environments can rapidly facilitate agri-food transformation in the region. In order to gather the stakeholders’ perception about this, we organized a collective conversation among ~400 stakeholders that represent various scales and sectors within the agriculture sector in MENA. These “listening cum learning consultations” were conducted through a survey followed by a series of webinars. The webinar discussions were strategically guided based on our hypothesis, the responses from the surveys and the regional needs. These discussions provided a forum to bring-out the stakeholders’ perspective on what new knowledge, partnerships, instruments and projects were needed in the MENA. The deliberation focused on the opportunities of public–private partnerships focusing in all the four major agroecosystems in MENA (irrigated, rainfed, rangelands, and deserts). In result, we developed an effective framework for strategic resource mobilization in the region, keeping in view the strong regional needs for climate actions and the requisite long-term commitments for the SDGs implementation.