Терапевтический архив (Jun 2010)

The first experience in using rituximab in Mikulicz's disease

  • V I Vasilyev,
  • S G Palshina,
  • M V Simonova,
  • O A Logvinenko,
  • S Kh Sedyshev,
  • B V Mitrikov,
  • N A Probatova,
  • N V Kokosadze,
  • T N Safonova,
  • E N Aleksandrova,
  • E L Nasonov

Journal volume & issue
Vol. 82, no. 6
pp. 62 – 66

Abstract

Read online

The paper describes a case of Mikulicz's disease (MD) in a young woman (aged 19 years) with symmetrical large salivary gland lesion concurrent with the enlarged lacrimal glands. Immunomorphological and molecular studies of parotid gland biopsy specimens revealed the formation of MALT tissue without signs of B-cell clonality of an infiltrate. The diagnosis of lacrimal sac lymphoma was ruled out. MD was diagnosed. The use of rituximab in therapy for MD has first demonstrated a positive result in Russian and worldwide practice.

Keywords