Frontiers in Cellular and Infection Microbiology (Nov 2021)
Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
- Runqiu Liu,
- Runqiu Liu,
- Runqiu Liu,
- Runqiu Liu,
- Cong Peng,
- Cong Peng,
- Cong Peng,
- Cong Peng,
- Cong Peng,
- Danrong Jing,
- Danrong Jing,
- Danrong Jing,
- Danrong Jing,
- Danrong Jing,
- Yangjian Xiao,
- Yangjian Xiao,
- Yangjian Xiao,
- Yangjian Xiao,
- Wu Zhu,
- Wu Zhu,
- Wu Zhu,
- Wu Zhu,
- Wu Zhu,
- Shuang Zhao,
- Shuang Zhao,
- Shuang Zhao,
- Shuang Zhao,
- Jianglin Zhang,
- Jianglin Zhang,
- Jianglin Zhang,
- Jianglin Zhang,
- Xiang Chen,
- Xiang Chen,
- Xiang Chen,
- Xiang Chen,
- Xiang Chen,
- Jie Li,
- Jie Li,
- Jie Li,
- Jie Li,
- Jie Li
Affiliations
- Runqiu Liu
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Runqiu Liu
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Runqiu Liu
- Department of Dermatology, The First People’s Hospital of Yancheng, Yancheng, China
- Runqiu Liu
- Department of Dermatology, The Fourth Affiliated Hospital of Nantong University, Nantong, China
- Cong Peng
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Cong Peng
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Cong Peng
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Cong Peng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Cong Peng
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Danrong Jing
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Danrong Jing
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Danrong Jing
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Danrong Jing
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Danrong Jing
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Yangjian Xiao
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Yangjian Xiao
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Yangjian Xiao
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Yangjian Xiao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Wu Zhu
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Wu Zhu
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Wu Zhu
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Wu Zhu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Wu Zhu
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Shuang Zhao
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Shuang Zhao
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Shuang Zhao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Shuang Zhao
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Jianglin Zhang
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Jianglin Zhang
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Jianglin Zhang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Jianglin Zhang
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Xiang Chen
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Xiang Chen
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Xiang Chen
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Xiang Chen
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Xiang Chen
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- Jie Li
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Jie Li
- Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
- Jie Li
- Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China
- Jie Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Jie Li
- Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fcimb.2021.703126
- Journal volume & issue
-
Vol. 11
Abstract
BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.MethodsA case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.ResultsThe alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. Subdoligranulum and Ruminococcus bromii decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI).ConclusionsThe gut microbiota of CSD patients is imbalanced. Subdoligranulum and Ruminococcus bromii are the gut microbiota biomarkers in CSD.
Keywords
- chronic spontaneous urticaria
- symptomatic dermographism
- gut microbiota
- Subdoligranulum
- Ruminococcus bromii
