Іndicators of systemic immunity and phagocytosis in patients suffering from acne with varying degrees of colon microbiota changes

Abstract

Aim. To identify the indicators of systemic immunity and phagocytosis in patients with acne with varying degrees of colon microbiota changes. Material and Methods. Under observation there were 117 patients with acne aged from 18 to 30 years among which 49 (41.88%) were male and 68 (58.12%) - female. In 42 (35.90%) patients mild acne were diagnosed, in 37 (31.62%) - moderate, in 29 (24.79%) - severe, and in 11 (9.40%) - cystic acne. 64 (54,70%) patients suffered from acne less than one 1 year, and 53 (45,30%) -from 1 to 3 years. The state of large intestine cavity microbiota in patients with acne was investigated using bacteriological technique,; for the assessment of the systemic immunity state and phagocytosis, immunological methods were used. Results and Discussion. In the majority of patients (N=93- 79,49%) suffering from acne, the presence of I-IV degree dysbiosis of large intestine cavity with mostly subclinical or latent clinical course was identified. The most significant changes in large intestine biocenosis were found in the patients with severe and cystic acne. In patients with acne, significant changes in indicators of systemic immunity and phagocytosis were found. These changes are the most significant in patients with dysbiosis of the II, III and, especially, IV degree. This may be one of the possible causes for development of secondary immunodeficiency state and burdened course in such patients. Conclusion. In patients with acne, changes in indicators of systemic immunity and phagocytosis were found. Such changes and the degree of associated dysbiosis of large intestine cavity, and severity of acne are interdependent. This justifies differentiated prescription of immunocorrecting drugs and probiotics to such patients.

Keywords

• acne, systemic immunity, phagocytosis, colon microbiota