Lens Thickness in Infants and Children with Cataracts

Libby Wei, MD; Taylor Kolosky; Sarah Byun; Alexandra S. Dolgetta, MD; Moran R. Levin, MD; Jana A. Friedman, MD; Monica M. Manrique, MD; Isabelle Dortonne, MD; Camilo Martinez, COA; Marlet Bazemore, MD; Mohamad S. Jaafar, MD; William P. Madigan, MD; Laurence Magder, PhD; Janet L. Alexander, MD, MS

Ophthalmology Science (Jan 2025)

Lens Thickness in Infants and Children with Cataracts

Libby Wei, MD,
Taylor Kolosky,
Sarah Byun,
Alexandra S. Dolgetta, MD,
Moran R. Levin, MD,
Jana A. Friedman, MD,
Monica M. Manrique, MD,
Isabelle Dortonne, MD,
Camilo Martinez, COA,
Marlet Bazemore, MD,
Mohamad S. Jaafar, MD,
William P. Madigan, MD,
Laurence Magder, PhD,
Janet L. Alexander, MD, MS

Affiliations

Libby Wei, MD: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Taylor Kolosky: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Sarah Byun: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Alexandra S. Dolgetta, MD: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Moran R. Levin, MD: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Jana A. Friedman, MD: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Monica M. Manrique, MD: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
Isabelle Dortonne, MD: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
Camilo Martinez, COA: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
Marlet Bazemore, MD: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
Mohamad S. Jaafar, MD: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
William P. Madigan, MD: Department of Ophthalmology, Children’s National Health System, Washington, District of Columbia
Laurence Magder, PhD: Department of Biostatistics, Epidemiology, and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Janet L. Alexander, MD, MS: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland; Correspondence: Janet L. Alexander, MD, MS, Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood St., Suite 479, Baltimore, MD 21201.

Journal volume & issue: Vol. 5, no. 1
p. 100588

Abstract

Read online

Purpose: The purpose of this study was to determine the association between lens thickness and cataract in participants aged 0 to 5 years. Design: This was a prospective, multicenter, case–control study. Participants: We enrolled 118 participants (171 eyes) aged 0 to 5 years, mean age 14.6 ± 17.0 months, range 0 to 60 months. Methods: Lens thickness was measured on 342 ultrasound biomicroscopy (UBM) images. Main Outcome Measures: Lens thickness; feasibility of lens thickness measurement from UBM images. Results: The mean lens thickness among noncataracts was 3.60 ± 0.17 mm, compared with 3.16 ± 0.61 mm among cataracts (P < 0.0001). Lens thickness <3.5 mm was significantly associated with increased odds of cataract; adjusted odds ratio = 5.99 (95% confidence interval, 2.41–14.88; P < 0.0003) among participants age 0 to 7 months. Lens thickness was significantly associated with cataract laterality among participants age 0 to 7 months (P < 0.0001). Conclusions: Quantitative UBM can be used to evaluate lens thickness in infants and children with congenital cataracts. The lens in congenital cataract eyes was thinner than that of controls among infants. Abnormal lens thickness was significantly associated with cataract. Future longitudinal studies will examine the association between lens thickness and postcataract surgery outcomes. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

About the journal

Abstract

Keywords