NAD+ metabolism controls inflammation during senescence

Abstract

We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence. This newly discovered epigenetic-metabolic signaling axis, mediated by high mobility group A and nicotinamide phosphoribosyltransferase, drives key metabolic changes and pro-inflammatory responses of senescent cells that fuel cancer progression.

Keywords

• cellular senescence
• senescence-associated secretory phenotype (sasp)
• nad+
• nampt
• hmga