Nature Communications (Dec 2019)
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
- Nils C. Gassen,
- Daniela Niemeyer,
- Doreen Muth,
- Victor M. Corman,
- Silvia Martinelli,
- Alwine Gassen,
- Kathrin Hafner,
- Jan Papies,
- Kirstin Mösbauer,
- Andreas Zellner,
- Anthony S. Zannas,
- Alexander Herrmann,
- Florian Holsboer,
- Ruth Brack-Werner,
- Michael Boshart,
- Bertram Müller-Myhsok,
- Christian Drosten,
- Marcel A. Müller,
- Theo Rein
Affiliations
- Nils C. Gassen
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Daniela Niemeyer
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Doreen Muth
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Victor M. Corman
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Silvia Martinelli
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Alwine Gassen
- Faculty of Biology, Genetics, Ludwig-Maximilian-University Munich (LMU)
- Kathrin Hafner
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Jan Papies
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Kirstin Mösbauer
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Andreas Zellner
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Anthony S. Zannas
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Alexander Herrmann
- HIV-Cell-Interactions Group, Institute of Virology, German Research Center for Environmental Health
- Florian Holsboer
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Ruth Brack-Werner
- HIV-Cell-Interactions Group, Institute of Virology, German Research Center for Environmental Health
- Michael Boshart
- Faculty of Biology, Genetics, Ludwig-Maximilian-University Munich (LMU)
- Bertram Müller-Myhsok
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Christian Drosten
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Marcel A. Müller
- Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Theo Rein
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- DOI
- https://doi.org/10.1038/s41467-019-13659-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.
