Arquivo Brasileiro de Medicina Veterinária e Zootecnia (Jun 2023)

Lipopolysaccharide effects on activation and apoptosis of primordial ovarian follicles in heifers

  • A.S. Maffi,
  • J.A. Alvarado. Rincón,
  • A.A. Barbosa,
  • M.A. Weiller,
  • R.G. Mondadori,
  • B.G. Gasperin,
  • M.T. Rovani,
  • L.A.X. Cruz,
  • K.C. Freitas,
  • A. Schneider,
  • M.N. Corrêa,
  • J.O. Feijó,
  • F.A.B. Del Pino,
  • V.R. Rabassa,
  • L. Marins,
  • C.C. Brauner

DOI
https://doi.org/10.1590/1678-4162-12848
Journal volume & issue
Vol. 75, no. 3
pp. 381 – 390

Abstract

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ABSTRACT The objective of the present study was to evaluate the effect of lipopolysaccharide (LPS) administration on activation and apoptosis of primordial follicles. There was no difference in the total number of follicles as well as in the different types of follicles. Furthermore, the LPS challenge didn’t modulate the expression of genes related with ovarian reserve (HAM), oocyte survival (Survivin), activation rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), and follicular abnormalities. Therefore, the LPS exposure with 24h interval had no effect on activation rate and primordial follicles abnormalities, and also had no effect on expression of anti-apoptotic genes and genes related with ovarian reserve, oocyte survival, activation rate, and primordial follicles abnormalities.

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