Nature Communications (Sep 2016)

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1

  • Takahiro Kishikawa,
  • Motoyuki Otsuka,
  • Takeshi Yoshikawa,
  • Motoko Ohno,
  • Hideaki Ijichi,
  • Kazuhiko Koike

DOI
https://doi.org/10.1038/ncomms13006
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation.