Synthesis of 2,4-disubstituted quinazolines promoted by deep eutectic solvent

Rajkumar Romeshkumar Singh; Thokchom Prasanta Singh; Thangjam Linda Devi; Thokchom Jeeta Devi; Okram Mukherjee Singh

Current Research in Green and Sustainable Chemistry (Jan 2021)

Synthesis of 2,4-disubstituted quinazolines promoted by deep eutectic solvent

Rajkumar Romeshkumar Singh,
Thokchom Prasanta Singh,
Thangjam Linda Devi,
Thokchom Jeeta Devi,
Okram Mukherjee Singh

Affiliations

Rajkumar Romeshkumar Singh: Chemistry Department, Manipur University, Canchipur, 795003, Manipur, India
Thokchom Prasanta Singh: Corresponding author.; Chemistry Department, Manipur University, Canchipur, 795003, Manipur, India
Thangjam Linda Devi: Chemistry Department, Manipur University, Canchipur, 795003, Manipur, India
Thokchom Jeeta Devi: Chemistry Department, Manipur University, Canchipur, 795003, Manipur, India
Okram Mukherjee Singh: Corresponding author.; Chemistry Department, Manipur University, Canchipur, 795003, Manipur, India

Journal volume & issue: Vol. 4
p. 100130

Abstract

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An efficient deep eutectic solvent (DES) promoted reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes (benzoyl alcohols) and ammonium acetate leading to the formation of quinazolines with excellent yields is described. The use of expensive catalysts and organic solvents are avoided in this protocol with the use of DES, which is biodegradable and renewable.

Published in Current Research in Green and Sustainable Chemistry

ISSN: 2666-0865 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/current-research-in-green-and-sustainable-chemistry

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