Zhongguo linchuang yanjiu (Dec 2023)
Correlation between protoporphyrin Ⅸ and hepatitis, cirrhosis, and liver cancer
Abstract
Objective To investigate the clinical significance of protoporphyrin Ⅸ (PPⅨ) in different stages of liver disease development, including hepatitis, cirrhosis, and liver cancer. Methods A total of 41 patients with chronic hepatitis (hepatitis group), 33 patients with liver cirrhosis (cirrhosis group), and 19 patients with liver cancer (liver cancer group) who visited the First Affiliated Hospital of Xi'an Medical University from January 2022 to December 2022 were selected as study object. Additionally, 40 healthy examinees during the same period were selected as the health control group. The basic information, blood routine, liver function, coagulation function, alpha fetoprotein (AFP)，controlled attenuation parameter (CAP)，liver stiffness measurement (LSM)，γ-glutamyl transpeptidase to platelet ratio (GPR) from each group were collected and compared. The correlation between various indicators and PPⅨ was analyzed. And the predictive value of PPⅨ and liver function related indicators on liver stiffness was analyzed. Results There were significant differences in gender, age, and PPⅨ between the hepatitis group, liver cirrhosis group, and liver cancer group compared to the control group (P<0.05). There were significant differences in total bilirubin (TBIL)，direct bilirubin (DBIL)，indirect bilirubin (IBIL)，total bile acid (TBA)，cholinesterase (CHE)，aspartate aminotransferase (AST)，alkaline phosphatase (ALP)，γ-glutamyl transpeptidase (γ-GT)，total protein (TP)，albumin (ALB) AFP, CAP, LSM and GPR between the hepatitis group, liver cirrhosis group, and liver cancer group (P<0.05). PPⅨ was positively correlated with AFP, TBIL, DBIL, IBIL, TBA, AST, ALP, LSM, GPR (r=0.359,0.350, 0.400, 0.299, 0.238, 0.238, 0.396, 0.235, 0.296, P<0.05). PPⅨ was negatively correlated with RBC, HB, PLT, CHE, ALB (r=-0.242, -0.219, -0.261, -0.341, -0.206, P<0.05). PPⅨ (AUC=0.623), TBIL (AUC=0.728), DBIL (AUC=0.797), and ALP (AUC=0.660) were valuable for predicting liver stiffness. Conclusion The level of PPⅨ in hepatitis patients is higher than that in healthy individuals, which can serve as a warning indicator for early liver function damage. The serum PPⅨ level is closely related to cholestasis and liver hardness, which is of great significance for clinical evaluation of the progression and prognosis of chronic liver disease.
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