Nature Communications (Apr 2016)
FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1
- Shahid Y. Khan,
- Shivakumar Vasanth,
- Firoz Kabir,
- John D. Gottsch,
- Arif O. Khan,
- Raghothama Chaerkady,
- Mei-Chong W. Lee,
- Carmen C. Leitch,
- Zhiwei Ma,
- Julie Laux,
- Rafael Villasmil,
- Shaheen N. Khan,
- Sheikh Riazuddin,
- Javed Akram,
- Robert N. Cole,
- C. Conover Talbot,
- Nader Pourmand,
- Norann A. Zaghloul,
- J. Fielding Hejtmancik,
- S. Amer Riazuddin
Affiliations
- Shahid Y. Khan
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- Shivakumar Vasanth
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- Firoz Kabir
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- John D. Gottsch
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- Arif O. Khan
- King Khaled Eye Specialist Hospital
- Raghothama Chaerkady
- Department of Biological Chemistry, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
- Mei-Chong W. Lee
- Department of Biomolecular Engineering, University of California
- Carmen C. Leitch
- Division of Endocrinology, Department of Medicine, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, Maryland 21201, USA
- Zhiwei Ma
- Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health
- Julie Laux
- Laboratory of Immunology, National Eye Institute, National Institutes of Health
- Rafael Villasmil
- Laboratory of Immunology, National Eye Institute, National Institutes of Health
- Shaheen N. Khan
- National Centre of Excellence in Molecular Biology, University of the Punjab
- Sheikh Riazuddin
- National Centre of Excellence in Molecular Biology, University of the Punjab
- Javed Akram
- Allama Iqbal Medical College, University of Health Sciences
- Robert N. Cole
- Department of Biological Chemistry, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
- C. Conover Talbot
- Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
- Nader Pourmand
- Department of Biomolecular Engineering, University of California
- Norann A. Zaghloul
- Division of Endocrinology, Department of Medicine, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, Maryland 21201, USA
- J. Fielding Hejtmancik
- Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health
- S. Amer Riazuddin
- The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- DOI
- https://doi.org/10.1038/ncomms10953
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Peter's Anomaly is a developmental disorder of the eye and has been linked to mutations in a range of genes, including the transcription factor FOXE3. Here the authors use next-generation RNA sequencing and mass spectrometry to identify an autophagy-associated protein, DNAJB1 as the transcriptional target of FOXE3.
