Fabrication data of two light-responsive systems to release an antileishmanial drug activated by infrared photothermal heating
Letícia S. Vitorino,
Thiago C. dos Santos,
Isabela A.A. Bessa,
Evelyn C.S. Santos,
Brunno R.F. Verçoza,
Luiz Augusto S. de Oliveira,
Juliany C.F. Rodrigues,
Célia M. Ronconi
Affiliations
Letícia S. Vitorino
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil
Thiago C. dos Santos
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil
Isabela A.A. Bessa
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil
Evelyn C.S. Santos
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil; Present address: Centro Brasileiro de Pesquisas Físicas, Urca-RJ, 22290-180, Brazil
Brunno R.F. Verçoza
Núcleo Multidisciplinar de Pesquisa em Biologia (NUMPEX-Bio), Campus UFRJ-Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ, Brazil
Luiz Augusto S. de Oliveira
Núcleo Multidisciplinar de Pesquisa em Nanotecnologia (NUMPEX-Nano), Campus UFRJ-Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ, Brazil
Juliany C.F. Rodrigues
Núcleo Multidisciplinar de Pesquisa em Biologia (NUMPEX-Bio), Campus UFRJ-Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ, Brazil
Célia M. Ronconi
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil; Corresponding author.
The data provided in this study are related to the fabrication of two light-responsive systems based on reduced graphene oxide (rGO) functionalized with the polymers Pluronic P123 (P123), rGO-P123, and polyethyleneimine (PEI), rGO-PEI, and loaded with amphotericin B (AmB), an antileishmanial drug. Here are described the experimental design to obtain the systems and characterization methods, such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Raman Spectroscopy, Powder X-Ray Diffraction, Transmission Electron Microscopy, Scanning Electron Microscopy and Thermogravimetric Analyses. Also, AmB spectroscopy studies are described. The materials rGO-P123 and rGO-PEI were loaded with AmB and the optimization of AmB and polymer fragments structures revealed several possible hydrogen bonds formed between the materials and the drug. The drug release was analyzed with and without Near-Infrared (NIR) light. In the studies conducted under NIR light irradiation for 10 min, an infrared lamp was disposed at 64 cm from the samples and an optical fiber thermometer was employed to measure the temperature variation. Cytotoxicity studies and antiproliferative assays against Leishmania amazonensis promastigotes were evaluated. The complete work data entitled Amphotericin-B-Loaded Polymer-Functionalized Reduced Graphene Oxides for Leishmania amazonensis Chemo-Photothermal Therapy have been published to Colloids and Surfaces B: Bionterfaces (https://doi.org/10.1016/j.colsurfb.2021.112169) [1].
