Nature Communications (Apr 2016)

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

  • Muhammad M. Mohiuddin,
  • Avneesh K. Singh,
  • Philip C. Corcoran,
  • Marvin L. Thomas III,
  • Tannia Clark,
  • Billeta G. Lewis,
  • Robert F. Hoyt,
  • Michael Eckhaus,
  • Richard N. Pierson III,
  • Aaron J. Belli,
  • Eckhard Wolf,
  • Nikolai Klymiuk,
  • Carol Phelps,
  • Keith A. Reimann,
  • David Ayares,
  • Keith A. Horvath

DOI
https://doi.org/10.1038/ncomms11138
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.