Nature Communications (Apr 2022)
EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma
- Emely Möller,
- Viviane Praz,
- Sanalkumar Rajendran,
- Rui Dong,
- Alexandra Cauderay,
- Yu-Hang Xing,
- Lukuo Lee,
- Carlo Fusco,
- Liliane C. Broye,
- Luisa Cironi,
- Sowmya Iyer,
- Shruthi Rengarajan,
- Mary E. Awad,
- Beverly Naigles,
- Igor Letovanec,
- Nicola Ormas,
- Giovanna Finzi,
- Stefano La Rosa,
- Fausto Sessa,
- Ivan Chebib,
- G. Petur Nielsen,
- Antonia Digklia,
- Dimitrios Spentzos,
- Gregory M. Cote,
- Edwin Choy,
- Martin Aryee,
- Ivan Stamenkovic,
- Gaylor Boulay,
- Miguel N. Rivera,
- Nicolò Riggi
Affiliations
- Emely Möller
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Viviane Praz
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Sanalkumar Rajendran
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Rui Dong
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Alexandra Cauderay
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Yu-Hang Xing
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Lukuo Lee
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Carlo Fusco
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Liliane C. Broye
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Luisa Cironi
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Sowmya Iyer
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Shruthi Rengarajan
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Mary E. Awad
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Beverly Naigles
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Igor Letovanec
- Department of Histopathology, Central Institute, Valais Hospital
- Nicola Ormas
- Department of Pathology, ASST Sette Laghi
- Giovanna Finzi
- Department of Pathology, ASST Sette Laghi
- Stefano La Rosa
- Institute of Pathology, Lausanne University Hospital and University of Lausanne
- Fausto Sessa
- Pathology Unit, Department of Medicine and Surgery, University of Insubria
- Ivan Chebib
- Department of Pathology, Massachusetts General Hospital and Harvard Medical School
- G. Petur Nielsen
- Department of Pathology, Massachusetts General Hospital and Harvard Medical School
- Antonia Digklia
- Department of Oncology, Lausanne University Hospital and University of Lausanne
- Dimitrios Spentzos
- Department of Orthopaedic Surgery, Massachusetts General Hospital
- Gregory M. Cote
- Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital
- Edwin Choy
- Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital
- Martin Aryee
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Ivan Stamenkovic
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- Gaylor Boulay
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Miguel N. Rivera
- Department of Pathology and Cancer Center, Massachusetts General Hospital
- Nicolò Riggi
- Experimental Pathology Service, Lausanne University Hospital and University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-022-29910-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The relationship between cellular histogenesis and molecular phenotypes for the EWSR1- ATF1 fusion in clear cell sarcoma (CCS) requires further characterization. Here, the authors investigate the EWSR1-ATF1 gene regulation networks in CCS cell lines, primary tumors, and mesenchymal stem cells.
