An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

Abstract

A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus <em>Taiwanofungus camphoratus </em>(<em>Antrodia camphorata</em>) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both <em>in vitro</em> and <em>in vivo</em>.

Keywords

• &lt;em&gt;Antrodia camphorata&lt;/em&gt;
• benzocamphorin F
• anti-inflammatory