Nature Communications (Aug 2022)
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
- Koji Hosomi,
- Mayu Saito,
- Jonguk Park,
- Haruka Murakami,
- Naoko Shibata,
- Masahiro Ando,
- Takahiro Nagatake,
- Kana Konishi,
- Harumi Ohno,
- Kumpei Tanisawa,
- Attayeb Mohsen,
- Yi-An Chen,
- Hitoshi Kawashima,
- Yayoi Natsume-Kitatani,
- Yoshimasa Oka,
- Hidenori Shimizu,
- Mari Furuta,
- Yoko Tojima,
- Kento Sawane,
- Azusa Saika,
- Saki Kondo,
- Yasunori Yonejima,
- Haruko Takeyama,
- Akira Matsutani,
- Kenji Mizuguchi,
- Motohiko Miyachi,
- Jun Kunisawa
Affiliations
- Koji Hosomi
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Mayu Saito
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Jonguk Park
- Laboratory of In-silico Drug Design, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Haruka Murakami
- Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Naoko Shibata
- Research Organization for Nano and Life Innovation, Waseda University
- Masahiro Ando
- Research Organization for Nano and Life Innovation, Waseda University
- Takahiro Nagatake
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Kana Konishi
- Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Harumi Ohno
- Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Kumpei Tanisawa
- Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Attayeb Mohsen
- Laboratory of In-silico Drug Design, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Yi-An Chen
- Laboratory of In-silico Drug Design, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Hitoshi Kawashima
- Laboratory of In-silico Drug Design, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Yayoi Natsume-Kitatani
- Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation Health and Nutrition (NIBIOHN)
- Yoshimasa Oka
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Hidenori Shimizu
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Mari Furuta
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Yoko Tojima
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Kento Sawane
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Azusa Saika
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Saki Kondo
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Yasunori Yonejima
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Haruko Takeyama
- Research Organization for Nano and Life Innovation, Waseda University
- Akira Matsutani
- Shunan City Shinnanyo Hospital
- Kenji Mizuguchi
- Laboratory of In-silico Drug Design, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Motohiko Miyachi
- Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- Jun Kunisawa
- Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
- DOI
- https://doi.org/10.1038/s41467-022-32015-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.
