THE DETERMINATION OF THE RHEOLOGICAL OPTIMUM OF OPHTHALMIC GELS. MODERN ASPECTS OF THE OPHTHALMIC DOSAGE FORMS DEVELOPMENT

Abstract

The article describes the main requirements for ophthalmic gels and presents the study of the rheological properties of ophthalmic gels, registered in the Russian Federation: Korneregel®, Solcoseryl®, Vidisic®, Ophtagel®, Oftan-Timogel®, Systein gel®. The parameters of rheological measurements conducted for ophthalmic gels are substantiated. On the basis of the results obtained, optimum rheological characteristics are suggested, which can be recommended for use in the development of ophthalmic gels.

Keywords

• ophthalmic gels
• ophthalmic dosage forms
• pharmacopeial requirements
• rotary viscosimetry
• plastic viscosity
• yield stress
• rheological optimum