Nature Communications (Oct 2019)

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

  • Luisa Capalbo,
  • Zuni I. Bassi,
  • Marco Geymonat,
  • Sofia Todesca,
  • Liviu Copoiu,
  • Anton J. Enright,
  • Giuliano Callaini,
  • Maria Giovanna Riparbelli,
  • Lu Yu,
  • Jyoti S. Choudhary,
  • Enrico Ferrero,
  • Sally Wheatley,
  • Max E. Douglas,
  • Masanori Mishima,
  • Pier Paolo D’Avino

DOI
https://doi.org/10.1038/s41467-019-12507-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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The midbody is an organelle present at the bridge connecting two cells at the end of cell division. Here, the authors use mass spectrometry to define the midbody interactome and uncover a role for PP1 phosphatases in microtubule dynamics and regulation of cytokinesis.