Can probiotic fermented milk products prevent early and late complications of antibiotic therapy in young children? (Results of an open randomized clinical trial)
A. I. Khavkin,
M. M. Gurova,
V. P. Novikova,
O. B. Fedotova,
D. V. Makarkin,
Yu. A. Koshkarova,
N. A. Penkina
Affiliations
A. I. Khavkin
Research Clinical Institute of Pediatrics named after Academician Yu. E. Veltischev of the Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» of the Ministry of Health of the Russian Federation
M. M. Gurova
Federal State budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation; Federal State Autonomous Educational Institution of Higher Education «Belgorod State University»; Saint Petersburg State budgetary Institution of Healthcare «Consultative and diagnostic center for children»
V. P. Novikova
Federal State budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation
O. B. Fedotova
All-Russian Research Institute of the Dairy Industry
D. V. Makarkin
JSC «PROGRESS»
Yu. A. Koshkarova
State Budgetary Healthcare Institution of the Moscow Region «Dmitrovskaya City Hospital»
N. A. Penkina
State Budgetary Healthcare Institution of the Moscow Region «Dmitrovskaya City Hospital»
The paper presents the results of a multicenter, open, randomized clinical trial aimed at assessing the protective properties of a fermented milk probiotic drink containing Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis (BB-12), enriched with prebiotic (inulin), zinc, calcium and vitamin D3 to prevent the development of early and late complications of antibiotic therapy in children aged 8 to 36 months with acute respiratory infection. The objectives of the study were to determine the incidence and severity of gastrointestinal disorders depending on the inclusion in the diet of a probiotic fermented milk drink for daily use for three months. The informative value of using the Brussels Infant and Toddler Stool Scale (BITSS) for young children in assessing the nature of stool in children with acute respiratory infection who received a course of antibiotic therapy was shown. It was found that taking a fermented milk probiotic drink containing Lactobacillus acidophilus, Bifidobacterium animalis subsp. lactis, inulin, zinc, calcium and vitamin D3 for three months, starting from the first day of antibiotic therapy, helps to maintain the stability of the consistency of feces during treatment and during the recovery period after it reduces the incidence of gastrointestinal disorders, the risk of early and late complications associated with taking antibiotics.
