Succinate detection in glomus jugulare paraganglioma on MRS as a marker for SDHB mutation

Abstract

Succinate dehydrogenase gene mutation (SDH) is known as a cause of familial paraganglioma, and the dysfunction of SDH leads to the accumulation of succinate in the cell. Succinate detection using 1H- Magnetic Resonance Spectroscopy is reported as a highly specific biomarker for SDH mutation, but the technical limitation in head and neck is causing difficulty detecting due to artifact such as fat contamination and magnetic field inhomogeneity. We are presenting a case of SDHB mutated paraganglioma in the jugular foramen, with successfully detection and quantification of the succinate peak in MRS with short acquisition time.

Keywords

• Succinate
• MRS
• SDH
• Paraganlioma