Fe-Gallic acid metal organic framework-encapsulated cellulose polymer thin film for fluorescent immunoassay of prostate-specific antigen

Sarah Alharthi; Mona N. Abou-Omar; Lamiaa Galal Amin; Safwat A. Mahmoud; Nora Hamad Al-Shaalan; Mohamed Mohamady Ghobashy; Esraa Elshahat; Taha F. Hassanein; Ekram H. Mohamed; Mohamed S. Attia

Results in Chemistry (Aug 2024)

Fe-Gallic acid metal organic framework-encapsulated cellulose polymer thin film for fluorescent immunoassay of prostate-specific antigen

Sarah Alharthi,
Mona N. Abou-Omar,
Lamiaa Galal Amin,
Safwat A. Mahmoud,
Nora Hamad Al-Shaalan,
Mohamed Mohamady Ghobashy,
Esraa Elshahat,
Taha F. Hassanein,
Ekram H. Mohamed,
Mohamed S. Attia

Affiliations

Sarah Alharthi: Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Mona N. Abou-Omar: Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
Lamiaa Galal Amin: Physics Department, Faculty of Science, Northern Border University, Arar, Saudi Arabia
Safwat A. Mahmoud: Physics Department, Faculty of Science, Northern Border University, Arar, Saudi Arabia
Nora Hamad Al-Shaalan: Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
Mohamed Mohamady Ghobashy: Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt
Esraa Elshahat: Clinical Pathology Department, Faculty of Medicine, Ain Sham University, Abbassia, Cairo 11566, Egypt
Taha F. Hassanein: Chemistry Department, Faculty of Science, Helwan University, 11795 Helwan, Cairo, Egypt
Ekram H. Mohamed: Analytical Chemistry Department, Faculty of Pharmacy, British University in Egypt, Egypt
Mohamed S. Attia: Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt; Corresponding author.

Journal volume & issue: Vol. 10
p. 101738

Abstract

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A novel, highly sensitive, and cost-effective biosensor for prostate-specific antigen (PSA) detection has been developed using bioengineered nanotechnology. This biosensor integrates a Fe(III)-Gallic acid metal organic framework (Fe-GA MOF) embedded in a carboxymethyl cellulose polymer thin film, coupled with a PSA monoclonal antibody for capture. The resulting sensor demonstrates exceptional performance in detecting PSA levels within a wide concentration range (0.1–170 ng/mL), with a remarkable limit of detection of 0.06 ng/mL. This advanced technology surpasses conventional methods by providing enhanced sensitivity, stability, and reduced interference. The biosensor holds immense potential for early prostate cancer diagnosis, monitoring treatment response, and detecting recurrence. Moreover, its applicability may extend to other cancers characterized by elevated PSA levels, ultimately improving patient outcomes through timely intervention and optimized care.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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