Nature Communications (Jan 2017)
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
- Liam A. Hurst,
- Benjamin J. Dunmore,
- Lu Long,
- Alexi Crosby,
- Rafia Al-Lamki,
- John Deighton,
- Mark Southwood,
- Xudong Yang,
- Marko Z. Nikolic,
- Blanca Herrera,
- Gareth J. Inman,
- John R. Bradley,
- Amer A. Rana,
- Paul D. Upton,
- Nicholas W. Morrell
Affiliations
- Liam A. Hurst
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Benjamin J. Dunmore
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Lu Long
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Alexi Crosby
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Rafia Al-Lamki
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- John Deighton
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Mark Southwood
- Department of Pathology, Papworth Hospital, Papworth Everard
- Xudong Yang
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Marko Z. Nikolic
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Blanca Herrera
- Department Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Calle Del Prof Martin Lagos
- Gareth J. Inman
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital And Medical School
- John R. Bradley
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Amer A. Rana
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Paul D. Upton
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- Nicholas W. Morrell
- Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals
- DOI
- https://doi.org/10.1038/ncomms14079
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth muscle cells to drive abnormal proliferation and PAH.
