High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Anita Rogic; Ila Pant; Luca Grumolato; Ruben Fernandez-Rodriguez; Andrew Edwards; Suvendu Das; Aaron Sun; Shen Yao; Rui Qiao; Shabnam Jaffer; Ravi Sachidanandam; Guray Akturk; Rosa Karlic; Mihaela Skobe; Stuart A. Aaronson

doi:10.1038/s41467-021-27108-8

Nature Communications (Nov 2021)

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Anita Rogic,
Ila Pant,
Luca Grumolato,
Ruben Fernandez-Rodriguez,
Andrew Edwards,
Suvendu Das,
Aaron Sun,
Shen Yao,
Rui Qiao,
Shabnam Jaffer,
Ravi Sachidanandam,
Guray Akturk,
Rosa Karlic,
Mihaela Skobe,
Stuart A. Aaronson

Affiliations

Anita Rogic: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Ila Pant: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Luca Grumolato: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Ruben Fernandez-Rodriguez: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Andrew Edwards: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Suvendu Das: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Aaron Sun: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Shen Yao: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Rui Qiao: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Shabnam Jaffer: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Ravi Sachidanandam: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Guray Akturk: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Rosa Karlic: Bioinformatics group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb
Mihaela Skobe: Laboratory of Cancer Lymphangiogenesis, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Stuart A. Aaronson: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-27108-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and implicating its high level of CCL2 in macrophage infiltration and tumor progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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